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Causes and Risk Factors

The cause of Peyronie's disease is unknown. Cases that develop suddenly are often caused by trauma to the penis (e.g., invasive penile procedure, injury, extremely vigorous sexual activity). Invasive penile procedures include urethral catheterization, cystoscopy and transurethral prostatectomy.

Cases of Peyronie's that develop over time may be caused by an inherited abnormality of human leukocyte antigen B27 (HLA-B27), suggesting a genetic link. Also, Peyronie's ..Read the full article